Application of Granular Computing Methods in Protein Classification

Bioinformatics integrates the best of computing with the field of biosciences to produce promising new algorithms and solutions for the advancement of drug development, analysis of diseases as well as for the understanding of the very components that all living beings are made up of. Genomics has been a highly focused area since the birth of bioinformatics and since then much work has been on the study of DNA, leading to cloning and also stem cell research. Another area of bioinformatics which has gathered much attention is proteomics or the study of proteins. Proteins, formed from chains of amino acids, are the components responsible for many bodily functions. Each protein has its own folding pattern and the final structure defines the functions it is made for. The cavities or docking sites of a protein are primarily responsible for interactions with other binding components. Research has been intensively carried out to predict the structure of a protein from its amino acid chain base as well as to classify the proteins according to their estimated functions. This research focuses on the integration of the ideas of granular computing into protein classification, targeting one of the most challenging areas in bioinformatics. Starting with the correct identification of the docksites of a protein, the research will proceed to classify the proteins through the analysis of these docksites. The final output will be analysed and compared to ab initio studies of proteins for accuracy testing.

Publications



poster
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